EGFR基因突变

TheidentificationofactivatingmutationsinEGFR,mostlyseeninexon19(deletion)orinexon21(LRpointmutation),togetherwithanincreasedsensitivitytoEGFRtyrosinekinaseinhibitors,hasbeenthefirstandmostimportantsteptowardmolecular-guidedprecisiontherapyoflungcancer.31,32WhereasEGFRmutationsareseenin10to20%ofwhitepatients,higherincidencerateshavebeenobservedamongpatientsofEastAsianorigin(approximately48%).33Theincidenceofthesemutationsalsocorrelateswiththehistologicfindingofadenocarcinoma,nopreviousorcurrentsmoking,youngerage,andfemalesex.34Inameta-analysis,randomizedtrialsoftheEGFRtyrosinekinaseinhibitorsgefitinib,erlotinib,andafatinibshowedsignificantimprovementsintheresponserateandprogression-freesurvival,as







































合肥较好的白癜风医院
盖百霖遮盖液能不能治好初发的白癜风